Big Pharma

The Game

Big Pharma by Twice Circled is a simulation game available on virtually every platform (except mobile). The game is a conveyer belt manufacturing simulator in which you combine various ingredients to create new and wonderful medicines to help people with their illnesses. Overall the concept is fairly simple, however the initial learning curve can be quite steep. There are quite a few tutorial missions and they can be quite daunting, but once you get to grips with the mechanics you’ll also realise that the game does quite a good job of telling you exactly what to do with each ingredient to achieve the desired effect. Note that I played the PS4 version, so some comments may be specific to that, the obvious benefit (as usual) of having a PC version is mods – although these aren’t available through the Steam Workshop as with other games, so may be a bit of a hassle.

The game features research trees and various exploration missions that you need to undertake in order to discover new ingredients and improve your machinery. At it’s most basic level the game is based around increasing or decreasing the concentration of various ingredients in order to achieve desired effects (these can be seen in the info panel of each ingredient). When at a certain concentration some ingredients can be combined with others or run through a specific machine in order to change or upgrade their effect completely. This is where the game gets interesting and a lot more complex. Combining various ingredients and increasing/decreasing their concentration until you achieve the perfect cure can be quite a complex process and if you don’t do it efficiently enough, you won’t be making much of a profit.

Worth it?

Generally speaking the game will set you back between £20-30. Honestly I find that a bit on the expensive side, so look out for any offers. It does offer a lot of scenarios to play through and a lot of depth and there’s a free build mode too. On PS4 the controls can be a bit of a challenge to get used to and don’t always feel very intuitive to use, it sort of goes without saying that it’s a game made for a PC.

Overall other than some control issues and the slightly elevated price, the game is quite addictive and can be really satisfying once you get that supply chain up and running properly, it has some really satisfying sound effects and will keep you coming back for more. There’s plenty of scenarios to keep you playing for a while and if you’re playing on PC you can even have a go with modding the game.


  • Keep an eye on each ingredient’s info card – it will tell you what concentration you have to get it to and what device you then need to use to get the desired effect
  • The info card will also tell you the total manufacturing cost and medicine value – don’t overextend for really good drugs early on as you won’t have the machinery to make the production line efficient enough and you’ll end up losing money
  • Hire researchers as soon as you can afford to so that you can begin researching better machinery – focus on the agglomerator and ioniser
  • If you can’t get rid of a negative side-effect, turn that medicine into a cream – it will reduce the negative score from the bad side-effect by 50%

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